Li Hi Shing Stacey, Chipika Rangariroyashe H, Finegan Eoin, Murray Deirdre, Hardiman Orla, Bede Peter
Computational Neuroimaging Group, Academic Unit of Neurology, Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
Front Neurol. 2019 Jul 16;10:773. doi: 10.3389/fneur.2019.00773. eCollection 2019.
Post-polio syndrome (PPS) is a neurological condition that affects polio survivors decades after their initial infection. Despite its high prevalence, the etiology of PPS remains elusive, mechanisms of progression are poorly understood, and the condition is notoriously under-researched. While motor dysfunction is a hallmark feature of the condition, generalized fatigue, sleep disturbance, decreased endurance, neuropsychological deficits, sensory symptoms, and chronic pain are also often reported and have considerable quality of life implications in PPS. The non-motor aspects of PPS are particularly challenging to evaluate, quantify, and treat. Generalized fatigue is one of the most distressing symptoms of PPS and is likely to be multifactorial due to weight-gain, respiratory compromise, poor sleep, and polypharmacy. No validated diagnostic, monitoring, or prognostic markers have been developed in PPS to date and the mainstay of therapy centers on symptomatic relief and individualized rehabilitation strategies such as energy conservation and muscle strengthening exercise regimes. Despite a number of large clinical trials in PPS, no effective disease-modifying pharmacological treatments are currently available.
小儿麻痹后遗症（PPS）是一种神经系统疾病，会在初次感染数十年后影响小儿麻痹症幸存者。尽管其发病率很高，但PPS的病因仍不明确，进展机制了解甚少，而且该病症的研究也非常不足。虽然运动功能障碍是该病症的一个标志性特征，但普遍疲劳、睡眠障碍、耐力下降、神经心理缺陷、感觉症状和慢性疼痛也经常被报告，并且对PPS患者的生活质量有相当大的影响。PPS的非运动方面在评估、量化和治疗上尤其具有挑战性。普遍疲劳是PPS最令人苦恼的症状之一，可能是由于体重增加、呼吸功能不全、睡眠不佳和多种药物治疗等多因素导致的。迄今为止，PPS尚未开发出经过验证的诊断、监测或预后标志物，治疗的主要方法是以症状缓解和个性化康复策略为中心，如节能和肌肉强化锻炼方案。尽管在PPS方面进行了多项大型临床试验，但目前尚无有效的疾病改善药物治疗方法。
