Ha Alice S, Riddle Robert D
Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, 1227 BRB II/III, Philadelphia, PA 19104, USA.
Gene Expr Patterns. 2003 Jun;3(3):297-300. doi: 10.1016/s1567-133x(03)00042-5.
Blimp is a transcriptional repressor that has been identified in humans, mice and frogs. Here, we describe the cloning of the gene that encodes for the chick homolog of Blimp, cBlimp-1, and the tempo-spatial expression pattern of cBlimp-1, during chick development. cBlimp-1 whose gene product shares a high level of identity with its homologs from other organisms, was found to be expressed in the apical ectodermal ridge and posterior dorsal ectoderm of developing limb buds. In addition, cBlimp-1 is expressed in the developing eyes, branchial arches and otic placodes.
Blimp是一种在人类、小鼠和青蛙中已被鉴定出的转录抑制因子。在此，我们描述了编码鸡Blimp同源物cBlimp-1的基因克隆，以及cBlimp-1在鸡胚胎发育过程中的时空表达模式。发现cBlimp-1的基因产物与其来自其他生物的同源物具有高度同源性，它在发育中的肢芽的顶端外胚层嵴和后背部外胚层中表达。此外，cBlimp-1在发育中的眼睛、鳃弓和耳基板中表达。
