Rodriguez-Galindo Carlos, Wilson Matthew W, Haik Barrett G, Lipson Mindy J, Cain Alvida, Merchant Thomas E, Kaste Sue, Pratt Charles B
Department of Hematology-Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Ophthalmology. 2003 Jun;110(6):1237-40. doi: 10.1016/S0161-6420(03)00258-6.
The risk for death in patients with retinoblastoma is increased in those who present with metastatic disease, and the role of intensive chemotherapy and autologous hematopoietic stem cell rescue in these patients remains unclear.
Nonrandomized interventional case series.
Four consecutive patients with metastatic retinoblastoma.
We treated four patients with retinoblastoma metastatic to the bone and bone marrow with intensive chemotherapy, consolidation with megatherapy, and autologous hematopoietic stem cell rescue. Chemotherapy included courses of carboplatin and etoposide alternating with cyclophosphamide, etoposide, and either carboplatin or cisplatin. Radiation therapy was delivered to areas of bone metastases.
Patient survival.
All patients completed and responded to the scheduled therapy; complete response of the bone marrow disease was documented after two courses of chemotherapy in all cases. Two patients are long-term survivors.
The treatment described has been successful in obtaining disease-free survival in patients with metastatic retinoblastoma.
患有视网膜母细胞瘤且出现转移性疾病的患者死亡风险会增加，强化化疗和自体造血干细胞救援在这些患者中的作用仍不明确。
非随机干预性病例系列。
连续4例转移性视网膜母细胞瘤患者。
我们对4例发生骨和骨髓转移的视网膜母细胞瘤患者进行了强化化疗、大剂量治疗巩固及自体造血干细胞救援。化疗方案包括卡铂和依托泊苷疗程与环磷酰胺、依托泊苷及卡铂或顺铂交替使用。对骨转移部位进行放射治疗。
患者生存率。
所有患者均完成了预定治疗并出现反应；所有病例在两个化疗疗程后均记录到骨髓疾病完全缓解。2例患者为长期存活者。
所描述的治疗方法已成功使转移性视网膜母细胞瘤患者实现无病生存。
