Srivani R, Nagarajan B
Department of Microbiology and Tumor Biochemistry, Cancer Institute, Adyar, Chennai, India.
Int J Gynecol Cancer. 2003 May-Jun;13(3):331-9. doi: 10.1046/j.1525-1438.2003.13197.x.
Interleukin-6 (IL-6) is a multifunctional cytokine with a growth promoting role in cancers. In an attempt to evaluate the prognostic significance of IL-6, we have studied the localization of this cytokine by immunohistochemical methods in normal, premalignant, and invasive cervical cancers. We stained frozen sections with a monoclonal antibody specific for human IL-6 and demonstrated that tumor cells show positivity with high intensity and stromal cells with moderate intensity. T cells and macrophages, components of the stroma that secrete IL-6, were also looked at. While T cells showed a weak positive correlation, CD68-positive macrophages showed significant positive correlation (P < 0.05) with IL-6 positivity in stroma. The patients were followed up for 40 months after treatment with standard radiotherapy regimen and showed residual tumor where pretreatment IL-6 levels were high. Our results suggest its possible candidature as a prognostic indicator of cervical cancer.
白细胞介素-6（IL-6）是一种多功能细胞因子，在癌症中具有促进生长的作用。为了评估IL-6的预后意义，我们采用免疫组化方法研究了这种细胞因子在正常、癌前和浸润性宫颈癌中的定位。我们用针对人IL-6的单克隆抗体对冰冻切片进行染色，结果显示肿瘤细胞呈高强度阳性，基质细胞呈中等强度阳性。我们还观察了分泌IL-6的基质成分T细胞和巨噬细胞。虽然T细胞呈弱阳性相关，但CD68阳性巨噬细胞与基质中IL-6阳性呈显著正相关（P < 0.05）。患者接受标准放疗方案治疗后随访40个月，结果显示在治疗前IL-6水平较高的部位出现了残留肿瘤。我们的结果表明，它可能是宫颈癌预后指标的候选者。
