Smola Sigrun
Institute of Virology, Saarland University Medical Center, Kirrbergerstr. Building 47, 66421, Homburg/Saar, Germany.
Papillomavirus Res. 2019 Jun;7:164-167. doi: 10.1016/j.pvr.2019.03.006. Epub 2019 Apr 10.
Evidence is emerging that a complex interplay between high-risk human papillomavirus infection, the local microenvironment and the immune system is critical for cervical carcinogenesis. To establish persistence, the virus has to evade or overcome immune control. At the transition from precancer to cancer, however, chronic stromal inflammation and immune deviation build up, which may eventually determine the course of disease. Understanding the molecular basis underlying these pivotal stage-specific changes may help to define new tools for better diagnosis and therapy that are required to efficiently combat human papillomavirus-associated disease.
越来越多的证据表明，高危型人乳头瘤病毒感染、局部微环境和免疫系统之间的复杂相互作用对宫颈癌的发生至关重要。为了建立持续性感染，该病毒必须逃避或克服免疫控制。然而，在从癌前病变向癌症转变的过程中，慢性基质炎症和免疫偏差逐渐形成，这最终可能决定疾病的进程。了解这些关键阶段特异性变化的分子基础，可能有助于确定新的工具，以实现更好的诊断和治疗，从而有效地对抗人乳头瘤病毒相关疾病。
