DeKosky Steven T
Department of Neurology, Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.
J Am Geriatr Soc. 2003 May;51(5 Suppl Dementia):S314-20. doi: 10.1046/j.1532-5415.5157.x.
As our understanding of the complex pathology of Alzheimer's disease improves, more targets for therapy emerge. These include the actions of beta amyloid, the inflammatory cascade, pathobiology of tau proteins' conversion to neurofibrillary tangles, oxidative neuronal damage, and neurotransmitter depletion. Many agents now under investigation target the early stages of the disease process, aiming to prevent or slow the development of symptoms. This article reviews the current understanding of the course and pathology of Alzheimer's disease as it relates to emerging therapies, then summarizes some promising current research directions in primary prevention, secondary prevention, and treatment.
随着我们对阿尔茨海默病复杂病理的认识不断提高，出现了更多的治疗靶点。这些靶点包括β淀粉样蛋白的作用、炎症级联反应、tau蛋白转化为神经原纤维缠结的病理生物学、氧化性神经元损伤以及神经递质耗竭。目前许多正在研究的药物针对疾病进程的早期阶段，旨在预防或减缓症状的发展。本文回顾了目前对阿尔茨海默病病程和病理的认识，以及与新兴疗法的关系，然后总结了在一级预防、二级预防和治疗方面一些有前景的当前研究方向。
