Panahloo Arshia, Mohamed-Ali Vidya, Gray Rosaire P, Humphries Steve E, Yudkin John S
Department of Medicine, Royal Free and University College Medical School, Holborn Union Building, Archway Campus, Archway Road, Highgate Hill, London N19 3UA, UK.
Atherosclerosis. 2003 Jun;168(2):297-304. doi: 10.1016/s0021-9150(03)00095-9.
High PAI-1 levels post acute myocardial infarction (AMI) are associated with a poor outcome. Concentrations of insulin-like molecules, proinflammatory cytokines and an insertion (5G)/deletion (4G) polymorphism in the promoter of the PAI-1 gene, all influence circulating PAI-1 levels. We studied the determinants of PAI-1 in 123 patients immediately following and at 6 months after AMI. Within 24 h of AMI, PAI-1 levels were related to those of proinsulin-like molecules but not to levels of cytokines (interleukin-1beta, interleukin-6 or tumour necrosis factor-alpha), to genotype, or to interactions between genotype and cytokine concentration. PAI-1 levels 6 months after AMI were related to concentrations of interleukin-1beta but not to genotype. We have found no evidence that subjects with the 4G/4G polymorphism have higher PAI-1 levels on admission or 6 months after AMI. In these patients, levels of PAI-1 are related to concentrations of proinsulin-like molecules and of proinflammatory cytokines.
急性心肌梗死（AMI）后纤溶酶原激活物抑制剂-1（PAI-1）水平升高与不良预后相关。胰岛素样分子、促炎细胞因子的浓度以及PAI-1基因启动子中的插入（5G）/缺失（4G）多态性均会影响循环中的PAI-1水平。我们对123例AMI患者在发病后即刻及6个月时PAI-1的决定因素进行了研究。AMI发病后24小时内，PAI-1水平与胰岛素原样分子水平相关，但与细胞因子（白细胞介素-1β、白细胞介素-6或肿瘤坏死因子-α）水平、基因型或基因型与细胞因子浓度之间的相互作用无关。AMI发病6个月后的PAI-1水平与白细胞介素-1β浓度相关，但与基因型无关。我们没有发现证据表明具有4G/4G多态性的受试者在入院时或AMI发病6个月后的PAI-1水平更高。在这些患者中，PAI-1水平与胰岛素原样分子和促炎细胞因子的浓度相关。
