Saunders J
Department of Medicinal Chemistry II, Glaxo Group Research, Greenford, Middlesex, UK.
Drug Des Discov. 1992 Jul;8(4):255-63.
A little less than two years ago, the first report describing non-nucleoside inhibitors of HIV reverse transcriptase (RT) led to the high anticipation that a range of new drugs could soon be available for the treatment of AIDS. The intervening period has given rise to several such agents but recent clinical trial data has indicated this optimism to be premature. This short review seeks to trace the brief history of the drug discovery process and to assess whether there are lessons to be learnt from the episode.
不到两年前，首篇描述HIV逆转录酶（RT）非核苷抑制剂的报告引发了人们的高度期待，即一系列新药可能很快就能用于治疗艾滋病。在此期间已经出现了几种这样的药物，但最近的临床试验数据表明，这种乐观情绪为时过早。这篇简短的综述旨在追溯药物研发过程的简短历史，并评估是否能从这一事件中吸取教训。
