Luck Suzanne, Torny Michael, d'Agapeyeff Katrina, Pitt Alison, Heath Paul, Breathnach Aoadhan, Russell Alison Bedford
St George's Hospital, London, UK.
Lancet. 2003 Jun 7;361(9373):1953-4. doi: 10.1016/S0140-6736(03)13553-2.
Estimates of incidence of early-onset group B streptococcal (EOGBS) infection are based on blood or cerebrospinal fluid culture-proven cases, which can be falsely negative and hence underestimate the true burden of disease. Probable EOGBS infection can be defined as colonisation by group B streptococci accompanied by features of clinical sepsis. Data collected prospectively in the UK over 1 year for neonates who required a septic screen in the first 72 h of life indicated a combined rate of definite and probable EOGBS infection of 3.6 per 1000 livebirths. This estimate indicates a much greater disease burden in the UK than that suggested by figures of culture-proven sepsis, and lends support to the need for prevention strategies.
早发型B族链球菌（EOGBS）感染发病率的估计是基于血培养或脑脊液培养确诊的病例，这些病例可能出现假阴性结果，因此低估了疾病的真实负担。疑似EOGBS感染可定义为B族链球菌定植并伴有临床败血症特征。在英国对出生后72小时内需进行败血症筛查的新生儿进行了为期1年的前瞻性数据收集，结果显示确诊和疑似EOGBS感染的综合发生率为每1000例活产中有3.6例。这一估计表明，英国的疾病负担比培养确诊败血症的数据所显示的要大得多，这也支持了采取预防策略的必要性。
