Derese Tadios Niguss, Wondafrash Mekdes Dereje, Teka Abel Melese, Mideksa Hiwot Soboksa, Mario Lidia Dagne, Hundie Tsegaye Gebreyes, Tilahun Robel Bayou, Demie Abel Abebe
Department of Research and Training, Eka Kotebe General Hospital, Addis Ababa, Ethiopia.
Department of Public Health, Kea Med Medical and Business College, Addis Ababa, Ethiopia.
PLOS Glob Public Health. 2025 Jul 14;5(7):e0004467. doi: 10.1371/journal.pgph.0004467. eCollection 2025.
Chorioamnionitis is a medical illness marked by maternal fever, leukocytosis, tachycardia, uterine discomfort, and preterm membrane rupture. Chorioamnionitis affects approximately 4% of full-term deliveries worldwide, but it is more common in preterm pregnancies and early membrane rupture. This study aimed to assess the prevalence and associated factors of chorioamnionitis among mothers in public hospitals in Addis Ababa, Ethiopia.A hospital-based cross-sectional study was conducted among maternity patients at Zewditu Memorial, Gandhi Memorial, and Abebech Gobena MCH Hospitals from June 15 to July 15, 2024. A simple random sampling technique with proportional size allocation was used to select a total sample of 379 patients. Data were collected using an interviewer-administered questionnaire and analyzed with SPSS version 26.Binary logistic regression was used to analyze the association between dependent and independent variables. Significance was set at p < 0.05 with a 95% confidence interval, and data were presented in tables and graphs.A total number of 356 patient's data were analysed and the proportion of patients with Chorioamnionitis was found to be 21.3%. After adjustment for possible confounders on multi-variable binary logistic regression analysis age < 25 years [AOR = 0.26, 95% CI (0.09-0.72)], having premature rupture of membrane [AOR = 2.24, 95% CI (1.05-4.78)], duration of labor < 12 hour [AOR = 0.10, 95% CI (0.04-0.24)], and having urinary tract infection [AOR = 3.54, 95% CI (1.72-7.27)] were the significant variable associated with Chorioamnionitis. Chorioamnionitis is a common complication in maternity patients. The magnitude of Chorioamnionitis in the selected public hospital was 21.3%. Age, premature rupture of membrane, duration of labor and urinary tract infection were the factors that had significant association with Chorioamnionitis. The Ministry of Health should focus on creating strategies to prevent and intervene in Chorioamnionitis for patients with premature rupture of membranes and prolonged labor.
绒毛膜羊膜炎是一种以母体发热、白细胞增多、心动过速、子宫不适和胎膜早破为特征的疾病。绒毛膜羊膜炎在全球足月分娩中约占4%，但在早产和胎膜早破中更为常见。本研究旨在评估埃塞俄比亚亚的斯亚贝巴公立医院母亲中绒毛膜羊膜炎的患病率及相关因素。2024年6月15日至7月15日，在泽维迪图纪念医院、甘地纪念医院和阿贝贝奇·戈贝纳妇幼保健医院对产妇进行了一项基于医院的横断面研究。采用按比例大小分配的简单随机抽样技术，共选取379例患者作为样本。通过访谈式问卷收集数据，并使用SPSS 26版进行分析。采用二元逻辑回归分析自变量和因变量之间的关联。显著性设定为p < 0.05，置信区间为95%，数据以表格和图表形式呈现。共分析了356例患者的数据，发现绒毛膜羊膜炎患者的比例为21.3%。在多变量二元逻辑回归分析中对可能的混杂因素进行调整后，年龄<25岁[AOR = 0.26，95% CI(0.09 - 0.72)]、胎膜早破[AOR = 2.24，95% CI(1.05 - 4.78)]、产程<12小时[AOR = 0.10，95% CI(0.04 - 0.24)]以及尿路感染[AOR = 3.54，95% CI(1.72 - 7.27)]是与绒毛膜羊膜炎相关的显著变量。绒毛膜羊膜炎是产妇常见的并发症。所选公立医院中绒毛膜羊膜炎的发生率为21.3%。年龄、胎膜早破、产程和尿路感染是与绒毛膜羊膜炎有显著关联的因素。卫生部应着重制定策略，对胎膜早破和产程延长的患者预防和干预绒毛膜羊膜炎。
