Steinman R M
Laboratory of Cellular Physiology & Immunology, The Rockefeller University, New York, NY 10021-6399, USA.
Pathol Biol (Paris). 2003 Mar;51(2):59-60. doi: 10.1016/s0369-8114(03)00096-8.
Dendritic cells (DCs) are best known for their roles in host resistance and immunogenicity. DCs provide a direct link between innate and adaptive immunity. After antigen capture and processing, DCs control the differentiation and polarization of T cells. However, there is a danger during the antigen presentation because, at the same time DCs are capturing microbial antigens and also dying self cells and environmental proteins, to which the immune system must not respond. There is good evidence that immature DCs, in the absence of infection and inflammation, induce immunological tolerance to innocuous self antigens, avoiding then a non-appropriate response to harmless antigens that may be presented subsequently when infection strikes.
树突状细胞（DCs）因其在宿主抵抗力和免疫原性方面的作用而最为人所知。DCs在固有免疫和适应性免疫之间提供了直接联系。在捕获和处理抗原后，DCs控制T细胞的分化和极化。然而，在抗原呈递过程中存在一个风险，因为DCs在捕获微生物抗原的同时，也会摄取自身死亡细胞和环境蛋白，而免疫系统不能对这些产生反应。有充分证据表明，在没有感染和炎症的情况下，未成熟的DCs会诱导对无害自身抗原的免疫耐受，从而避免在感染发生时对随后可能呈递的无害抗原产生不适当的反应。
