肠道与大脑
Gut and mind.
作者信息
Neary N M, Small C J, Bloom S R
机构信息
Department of Metabolic Medicine, Faculty of Medicine, Imperial College of Science, Technology, and Medicine, Hammersmith Campus, Du Cane Road, London W12 0NN, UK.
出版信息
Gut. 2003 Jul;52(7):918-21. doi: 10.1136/gut.52.7.918.
Abstract
Obesity is a growing epidemic, causally associated with a number of serious medical conditions, including diabetes mellitus, coronary heart disease, and several cancers. The gut hormones ghrelin and peptide YY are secreted from the gut in response to changes to nutritional status. While food intake is stimulated by ghrelin, it is inhibited by peptide YY. The discovery, anatomy, and physiology of ghrelin and peptide YY are discussed, focusing on the adaptive changes in diseases such as obesity and anorexia nervosa. Ghrelin and PYY are important therapeutic targets in the quest to find an effective antiobesity treatment.
摘要
肥胖是一种日益普遍的流行病，与多种严重疾病存在因果关系，包括糖尿病、冠心病和几种癌症。肠道激素胃饥饿素和肽YY会根据营养状况的变化从肠道分泌出来。胃饥饿素会刺激食物摄入，而肽YY则会抑制食物摄入。本文讨论了胃饥饿素和肽YY的发现、解剖结构和生理学，重点关注肥胖症和神经性厌食症等疾病中的适应性变化。在寻找有效的抗肥胖治疗方法的过程中，胃饥饿素和肽YY是重要的治疗靶点。
相似文献
1
Gut and mind.肠道与大脑
Gut. 2003 Jul;52(7):918-21. doi: 10.1136/gut.52.7.918.
2
Peptide YY levels are elevated after gastric bypass surgery.胃旁路手术后肽YY水平升高。
Obesity (Silver Spring). 2006 Feb;14(2):194-8. doi: 10.1038/oby.2006.25.
3
Changes in GI hormones and their effect on gastric emptying and transit times after Roux-en-Y gastric bypass in rat model.大鼠Roux-en-Y胃旁路术后胃肠激素的变化及其对胃排空和转运时间的影响
Surgery. 2005 Aug;138(2):283-90. doi: 10.1016/j.surg.2005.05.013.
4
Peptide YY and glucagon-like peptide-1 contribute to decreased food intake after Roux-en-Y gastric bypass surgery.肽YY和胰高血糖素样肽-1有助于降低Roux-en-Y胃旁路手术后的食物摄入量。
Int J Obes (Lond). 2016 Nov;40(11):1699-1706. doi: 10.1038/ijo.2016.121. Epub 2016 Aug 30.
5
Changes in appetite-regulating hormones following food intake are associated with changes in reported appetite and a measure of hedonic eating in girls and young women with anorexia nervosa.进食后调节食欲的激素变化与神经性厌食症女孩和年轻女性报告的食欲和享乐性进食的衡量标准的变化有关。
Psychoneuroendocrinology. 2020 Mar;113:104556. doi: 10.1016/j.psyneuen.2019.104556. Epub 2019 Dec 23.
6
Investigation of peptide YY and ghrelin responses to a test meal in bulimia nervosa.神经性贪食症患者对试餐的肽YY和胃饥饿素反应的研究。
Biol Psychiatry. 2005 Apr 15;57(8):926-31. doi: 10.1016/j.biopsych.2005.01.004.
7
Ghrelin and peptide YY levels after a variant of biliopancreatic diversion with Roux-en-Y gastric bypass versus after colectomy: a prospective comparative study.胆胰转流并Roux-en-Y胃旁路术后与结肠切除术后胃饥饿素和肽YY水平：一项前瞻性对比研究
Obes Surg. 2006 Jun;16(6):752-8. doi: 10.1381/096089206777346772.
8
9
Bariatric surgery and the gut-brain communication--the state of the art three years later.减重手术与肠道-脑通讯——三年后的最新进展。
Nutrition. 2010 Oct;26(10):925-31. doi: 10.1016/j.nut.2009.11.018. Epub 2010 Apr 14.
引用本文的文献
1
The Role of the Autonomic Nervous System in the Pathophysiology of Obesity.自主神经系统在肥胖病理生理学中的作用。
Front Physiol. 2017 Sep 14;8:665. doi: 10.3389/fphys.2017.00665. eCollection 2017.
2
PGC-1α expression in murine AgRP neurons regulates food intake and energy balance.小鼠AgRP神经元中PGC-1α的表达调节食物摄入和能量平衡。
Mol Metab. 2016 May 18;5(7):580-588. doi: 10.1016/j.molmet.2016.05.008. eCollection 2016 Jul.
3
Brain-gut axis in the pathogenesis of Helicobacter pylori infection.幽门螺杆菌感染发病机制中的脑-肠轴
World J Gastroenterol. 2014 May 14;20(18):5212-25. doi: 10.3748/wjg.v20.i18.5212.
4
The role of "mixed" orexigenic and anorexigenic signals and autoantibodies reacting with appetite-regulating neuropeptides and peptides of the adipose tissue-gut-brain axis: relevance to food intake and nutritional status in patients with anorexia nervosa and bulimia nervosa.“混合性”促食欲和抑食欲信号以及与食欲调节神经肽和脂肪组织-肠道-脑轴肽类发生反应的自身抗体的作用：与神经性厌食症和神经性贪食症患者的食物摄入及营养状况的相关性
Int J Endocrinol. 2013;2013:483145. doi: 10.1155/2013/483145. Epub 2013 Sep 9.
5
Ghrelin receptor antagonism decreases alcohol consumption and activation of perioculomotor urocortin-containing neurons.生长激素释放肽受体拮抗剂可减少酒精摄入量和眶周运动皮质内含有尿皮质素的神经元的激活。
Alcohol Clin Exp Res. 2010 Sep 1;34(9):1525-34. doi: 10.1111/j.1530-0277.2010.01237.x. Epub 2010 Jun 25.
6
Postprandial ghrelin and PYY responses of male subjects on low carbohydrate meals to varied balancing proportions of proteins and fats.男性受试者在低碳水化合物膳食中，不同蛋白质与脂肪平衡比例对餐后生长激素释放肽和肽 YY 的反应。
Eur J Nutr. 2010 Dec;49(8):493-500. doi: 10.1007/s00394-010-0108-9. Epub 2010 Apr 16.
7
Distribution of neuropeptide F-like immunoreactivity in the Eastern Subterranean termite, Reticulitermes flavipes.东方蜚蠊（Reticulitermes flavipes）中神经肽 F 样免疫反应的分布。
J Insect Sci. 2008;8:1-18. doi: 10.1673/031.008.6801.
8
Weight loss during oligofructose supplementation is associated with decreased ghrelin and increased peptide YY in overweight and obese adults.在超重和肥胖成年人中，补充低聚果糖期间体重减轻与胃饥饿素减少和肽YY增加有关。
Am J Clin Nutr. 2009 Jun;89(6):1751-9. doi: 10.3945/ajcn.2009.27465. Epub 2009 Apr 22.
9
Differential secretion of satiety hormones with progression of obesity in JCR:LA-corpulent rats.JCR:LA肥胖大鼠中饱腹感激素分泌随肥胖进展的差异
Obesity (Silver Spring). 2008 Apr;16(4):736-42. doi: 10.1038/oby.2007.128. Epub 2008 Jan 24.
10
Relation of fasting plasma peptide YY to glucose metabolism and cardiovascular risk factors after restrictive bariatric surgery.限制性减肥手术后空腹血浆肽YY与糖代谢及心血管危险因素的关系。
Wien Klin Wochenschr. 2007;119(9-10):291-6. doi: 10.1007/s00508-007-0776-5.
本文引用的文献
1
Antagonism of ghrelin receptor reduces food intake and body weight gain in mice.胃饥饿素受体拮抗剂可减少小鼠的食物摄入量和体重增加。
Gut. 2003 Jul;52(7):947-52. doi: 10.1136/gut.52.7.947.
2
Role of ghrelin in the control of growth hormone secretion in prepubertal rats: interactions with excitatory amino acids.胃饥饿素在青春期前大鼠生长激素分泌调控中的作用：与兴奋性氨基酸的相互作用。
Neuroendocrinology. 2003 Feb;77(2):83-90. doi: 10.1159/000068652.
3
The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats.胃传入迷走神经在大鼠胃饥饿素诱导进食及生长激素分泌中的作用
Gastroenterology. 2002 Oct;123(4):1120-8. doi: 10.1053/gast.2002.35954.
4
Gut hormone PYY(3-36) physiologically inhibits food intake.肠道激素PYY(3-36)在生理上抑制食物摄入。
Nature. 2002 Aug 8;418(6898):650-4. doi: 10.1038/nature00887.
5
Meal patterns and obesity in Swedish women-a simple instrument describing usual meal types, frequency and temporal distribution.瑞典女性的饮食模式与肥胖——一种描述常见饮食类型、频率和时间分布的简易工具
Eur J Clin Nutr. 2002 Aug;56(8):740-7. doi: 10.1038/sj.ejcn.1601387.
6
Peptide YY secretion in morbidly obese patients before and after vertical banded gastroplasty.病态肥胖患者垂直绑带胃成形术前后的肽YY分泌情况。
Obes Surg. 2002 Jun;12(3):324-7. doi: 10.1381/096089202321088084.
7
Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery.饮食诱导性体重减轻或胃旁路手术后的血浆胃饥饿素水平。
N Engl J Med. 2002 May 23;346(21):1623-30. doi: 10.1056/NEJMoa012908.
8
Peripheral ghrelin selectively increases Fos expression in neuropeptide Y - synthesizing neurons in mouse hypothalamic arcuate nucleus.外周胃饥饿素选择性增加小鼠下丘脑弓状核中神经肽Y合成神经元的Fos表达。
Neurosci Lett. 2002 May 31;325(1):47-51. doi: 10.1016/s0304-3940(02)00241-0.
9
The arcuate nucleus as a conduit for diverse signals relevant to energy homeostasis.弓状核作为与能量平衡相关的多种信号的传导通路。
Int J Obes Relat Metab Disord. 2001 Dec;25 Suppl 5:S63-7. doi: 10.1038/sj.ijo.0801913.
10
Ghrelin enhances appetite and increases food intake in humans.胃饥饿素可增强人类的食欲并增加食物摄入量。
J Clin Endocrinol Metab. 2001 Dec;86(12):5992. doi: 10.1210/jcem.86.12.8111.
Zotero 插件