Austin Christopher P, Ma Lei, Ky Betty, Morris Jill A, Shughrue Paul J
Department of Neuroscience, Merck Reserach Laboratories, West Point, PA 19486, USA.
Neuroreport. 2003 May 23;14(7):951-4. doi: 10.1097/01.wnr.0000074342.81633.63.
Disrupted in Schizophrenia-1 (DISC1) was identified as truncated by a balanced translocation segregating with schizophrenia and other major mental illness in a large Scottish family. As a step in evaluating the function of DISC1 and its potential role in human schizophrenia, we have determined its regional expression in the primate brain by in situ hybridization. DISC1 expression is highly localized, with most prominent expression in the dentate gyrus of the hippocampus and lateral septum, and lower levels of expression in the cerebral cortex, amygdala, paraventricular hypothalamus, cerebellum, interpeduncular nucleus, and subthalamic nucleus. Given that many of these regions have been implicated in schizophrenia pathogenesis, these results suggest brain circuits through which DISC1 truncation may predispose to schizophrenia.
精神分裂症相关基因1（DISC1）最初是在一个苏格兰大家族中被发现的，它因平衡易位而截短，并与精神分裂症和其他主要精神疾病相关联。作为评估DISC1功能及其在人类精神分裂症中潜在作用的一个步骤，我们通过原位杂交确定了它在灵长类动物大脑中的区域表达。DISC1的表达高度局限，在海马齿状回和外侧隔核中表达最为显著，而在大脑皮层、杏仁核、室旁下丘脑、小脑、脚间核和丘脑底核中的表达水平较低。鉴于这些区域中的许多都与精神分裂症的发病机制有关，这些结果提示了DISC1截短可能导致精神分裂症的脑回路。
