苯巴比妥根据其引起的肿瘤细胞死亡类型改变环磷酰胺的抗肿瘤作用。
Phenobarbital modifies antitumor effect of cyclophosphamide depending on the type of tumor cell death caused by it.
作者信息
Kaledin V I, Nikolin V P, Baimak T Yu, Galyamova M R, Popova N A, Andreeva E M
机构信息
Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk.
出版信息
Bull Exp Biol Med. 2003 Mar;135(3):289-92. doi: 10.1023/a:1024101518194.
Antitumor effect of cyclophosphamide on LS and P388 tumors is realized via apoptosis and on HA-1 and Krebs-2 tumors resistant to apoptosis via necrosis of tumor cells. Phenobarbital induction of cyclophosphamide-metabolizing enzymes decreases and cimetidine inhibition potentiates the effect of cyclophosphamide on LS and P388 cells and does not modulate the effect on HA-1 and Krebs-2 cells. Presumably, apoptosis and necrosis of tumor cell are induced by different cyclophosphamide metabolites.
环磷酰胺对LS和P388肿瘤的抗肿瘤作用是通过细胞凋亡实现的，而对HA - 1和Krebs - 2等抗细胞凋亡肿瘤则是通过肿瘤细胞坏死实现的。苯巴比妥诱导的环磷酰胺代谢酶减少，西咪替丁抑制则增强环磷酰胺对LS和P388细胞的作用，且不调节对HA - 1和Krebs - 2细胞的作用。据推测，肿瘤细胞的凋亡和坏死是由不同的环磷酰胺代谢产物诱导的。
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