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肌肽在体内脑氧化代谢受损期间对铜锌超氧化物歧化酶的保护作用。

Protective effect of carnosine on Cu,Zn-superoxide dismutase during impaired oxidative metabolism in the brain in vivo.

作者信息

Stvolinskii S L, Fedorova T N, Yuneva M O, Boldyrev A A

机构信息

Institute of Neurology, Russian Academy of Medical Sciences, Moscow.

出版信息

Bull Exp Biol Med. 2003 Feb;135(2):130-2. doi: 10.1023/a:1023855428130.

DOI:10.1023/a:1023855428130
PMID:12802415
Abstract

Natural hydrophilic antioxidant carnosine protects cerebral cytosolic Cu,Zn-superoxide dismutase (SOD) under conditions of oxidative stress in various in vivo models: short-term hypobaric hypoxia in rats and accumulation of age-related changes in senescence-accelerated mice (SAMP). Administration of carnosine preventing Cu,Zn-SOD inactivation reduced mortality in rats and prolonged average life span in SAMP-mice.

摘要

天然亲水性抗氧化剂肌肽在多种体内模型的氧化应激条件下保护大脑胞质铜锌超氧化物歧化酶（SOD）：大鼠的短期低压缺氧以及衰老加速小鼠（SAMP）中与年龄相关变化的积累。给予肌肽可防止铜锌超氧化物歧化酶失活，降低大鼠死亡率并延长SAMP小鼠的平均寿命。

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