新型抗孕激素与人类增生期子宫内膜中孕激素受体的相对结合活性
Relative binding activity of new antigestagens with progesterone receptors in human hyperplastic endometrium.
作者信息
Kamernitskii A V, Levina I S, Kareva E N, Kirpichnikova N V, Mgdesyan K K, Ovchinnikova E V
机构信息
Laboratory of Steroids and Terpenoids, Institute of Organic Chemistry, Russian Academy of Sciences, Moscow.
出版信息
Bull Exp Biol Med. 2002 Nov;134(5):445-7. doi: 10.1023/a:1022682028745.
We determined the content and binding capacity of progesterone receptors in the endometrium of patients with adenomatous and fibroid polyps, adenocystic hyperplasia, and atypical hyperplasia before and after gestagen therapy. Hyperplasia of the endometrium was accompanied by changes in affinity of cytosolic progesterone receptors for antigestagens, which provides the possibility of individual correction of hormone therapy.
我们测定了患有腺瘤性息肉、纤维瘤性息肉、腺囊性增生和非典型增生的患者在孕激素治疗前后子宫内膜中孕激素受体的含量和结合能力。子宫内膜增生伴随着胞质孕激素受体对抗孕激素亲和力的变化，这为激素治疗的个体化调整提供了可能。
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