Vysotskiĭ M M, Krasnova I A, Kostyleva O I, Eremin V L
Akush Ginekol (Mosk). 1993(6):46-9.
Estradiol and progesterone cytosol receptors, tamoxifen relative binding capacity in endometrial tissue samples, serum estradiol and progesterone levels were studied in 60 postmenopausal patients with hyperplastic processes in the endometrium. Estradiol and progesterone receptor levels were increased in glandular cystic polyp tissue, in atypical hyperplastic tissue samples, and in well-differentiated adenocarcinoma tissue. High estradiol levels were detected in the blood sera of patients with glandular cystic polyps, atypical and glandular hyperplasia. Tamoxifen relative binding capacity was the highest in glandular cystic polyps and glandular hyperplasia. Forty patients were treated with 17-hydroxyprogesterone capronate. The data on the status of cytosol receptors and tamoxifen relative binding capacity as well as clinical findings give grounds to include antiestrogens into therapeutic complex for postmenopausal patients with endometrial hyperplasia.
对60例绝经后子宫内膜增生患者的子宫内膜组织样本中的雌二醇和孕酮胞浆受体、他莫昔芬相对结合能力、血清雌二醇和孕酮水平进行了研究。在腺囊性息肉组织、非典型增生组织样本和高分化腺癌组织中，雌二醇和孕酮受体水平升高。在腺囊性息肉、非典型增生和腺性增生患者的血清中检测到高雌二醇水平。他莫昔芬相对结合能力在腺囊性息肉和腺性增生中最高。40例患者接受了己酸17-羟孕酮治疗。关于胞浆受体状态、他莫昔芬相对结合能力的数据以及临床发现为将抗雌激素纳入绝经后子宫内膜增生患者的治疗方案提供了依据。
