Bershtein L M, Tsyrlina E V, Poroshina T E, Rozanov Yu M, Gamayunova V B, Vasil'ev D A, Kovalenko I G
N. N. Petrov Institute of Oncology, Russian Ministry of Health, St. Petersburg.
Bull Exp Biol Med. 2002 Nov;134(5):485-8. doi: 10.1023/a:1022606801429.
We studied the influence of various methods for correction of age-related changes (administration of N-acetyl-L-cysteine, vitamins C and E, melatonin, and carnosine and swimming training) on the realization of estrogens effects in ovariectomized rats. The proliferation index in the endometrium decreased in 12-14-month-old control animals. The weight of the uterus, percentage of "comets", and average length of their tail in estradiol-treated rats far surpassed the corresponding parameters in control animals. Administration of melatonin and N-acetyl-L-cysteine and swimming training corrected these genotoxic abnormalities. Our results indicate that aging induces incomplete variant of the phenomenon for switching of estrogen's effects (increase in the severity of genotoxic damage without facilitation of the hormonal effect). These methods for correction of age-related changes have not only common, but also distinguishing characteristics compared to correction of changed induced by drinking of ethanol in various concentrations, whole body gamma-irradiation, and exposure to tobacco smoke.
我们研究了多种纠正与年龄相关变化的方法（给予N-乙酰-L-半胱氨酸、维生素C和E、褪黑素、肌肽以及进行游泳训练）对去卵巢大鼠雌激素效应实现的影响。12至14月龄的对照动物子宫内膜增殖指数降低。接受雌二醇治疗的大鼠子宫重量、“彗星”百分比及其尾巴平均长度远远超过对照动物的相应参数。给予褪黑素和N-乙酰-L-半胱氨酸以及进行游泳训练纠正了这些基因毒性异常。我们的结果表明，衰老诱导了雌激素效应转换现象的不完全变体（基因毒性损伤严重程度增加而激素效应未得到促进）。与不同浓度乙醇饮用、全身γ射线照射和接触烟草烟雾所诱导变化的纠正相比，这些纠正与年龄相关变化的方法不仅具有共同特征，还具有独特特征。
