Nepomnyashchikh L M, Aidagulova S V, Senchukova S R, Demidova E I
Department of General Pathology and Pathomorphology, Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk.
Bull Exp Biol Med. 2002 Nov;134(5):494-9. doi: 10.1023/a:1022610902337.
We studied skin biopsy specimens from patients with allergic dermatoses associated with opisthorchiasis. Structural changes in the epidermis and derma were presented by degenerative and destructive changes in epitheliocytes with a pronounced membranolytic component, hemodynamic disturbances in the derma, disorganization of the connective tissue, and progressive fibrosis. Combination therapy including antihelmintic drug produced a positive effect, which was associated with induction of regenerative processes in basal epidermal cells, stabilization of the basal membrane, and normalization of the dermoepidermal junction. Our findings indicate that opisthorchiasis plays an important role in the pathogenesis of allergic dermatoses.
我们研究了与华支睾吸虫病相关的过敏性皮肤病患者的皮肤活检标本。表皮和真皮的结构变化表现为上皮细胞的退行性和破坏性变化，伴有明显的膜溶解成分、真皮血流动力学紊乱、结缔组织紊乱和进行性纤维化。包括抗蠕虫药物在内的联合治疗产生了积极效果，这与诱导基底表皮细胞再生过程、稳定基底膜以及使真皮表皮连接正常化有关。我们的研究结果表明，华支睾吸虫病在过敏性皮肤病的发病机制中起重要作用。
