低温无灌注条件下药物性及冷停搏液停搏时心肌代谢及心肌微血管超微结构的变化
Changes in myocardial metabolism and ultrastructure of myocardial microvessels during pharmacological and cold cardioplegia under hypothermic conditions without perfusion.
作者信息
Kazanskaya G M, Volkov A M, Tsvetovskaya G A, Kniaz'kova L G, Chasovskikh G G, Diakonitsa T M, Zhdanov G P, Lomivorotov V N
机构信息
E.N.Meshalkin Institute of Circulation Pathology, Ministry of Health of Russia.
出版信息
Bull Exp Biol Med. 2002 Nov;134(5):500-4. doi: 10.1023/a:1022662919176.
A combination of pharmacological and cold cardioplegia in with hypothermia without perfusion in open-heart surgery guarantee the reversible character of shifts in energy and free radical balance in the myocardium. However, this procedure can impair coronary micricirculation due to structural and functional changes in microvessel endothelium. Our results demonstrate that new cytoprotective approaches are extremely needed for cardiac protection during surgery.
在心脏直视手术中，将药理学方法与冷心脏停搏液相结合，并在低温且无灌注的情况下，可确保心肌能量和自由基平衡变化的可逆性。然而，由于微血管内皮的结构和功能改变，该手术过程可能会损害冠状动脉微循环。我们的结果表明，在手术期间进行心脏保护时，极其需要新的细胞保护方法。
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