Phillips S J, Zeff R H, Kongtahworn C, Iannone L A, Brown T M, Gordon D F
Ann Surg. 1979 Jul;190(1):80-3. doi: 10.1097/00000658-197907000-00018.
Appropriately applied, hypothermic cardioplegia allows an excellent surgical setting that can significantly reduce the myocardial ischemic injury resulting from anoxia. One thousand eighty adult and pediatric patients underwent a variety of corrective cardial surgical procedures utilizing cold potassium cardioplegic solution injected into the coronary arteries via the aortic root. Myocardial septal temperature was maintained at 18--20 degrees during arrested time. This group of patients was compared to a group of 220 patients that underwent intermittent normothermic ischemic arrest to perform cardiac surgical procedures. Significant reduction in morbidity, mortality, perioperative myocardial infarction was noted in favor of the cardioplegic group. Metabolic coronary sinus blood analysis in the group undergoing surgery with cardioplegia revealed favorable changes in myocardial lactate and oxygen extraction.
适当应用低温心脏停搏液可提供极佳的手术条件，能显著减轻缺氧所致的心肌缺血损伤。1080例成人及儿童患者接受了各种心脏矫正手术，术中通过主动脉根部向冠状动脉注入冷钾心脏停搏液。心脏停搏期间心肌间隔温度维持在18 - 20度。将这组患者与220例接受间歇性常温缺血停搏以进行心脏手术的患者进行比较。结果显示，心脏停搏液组在发病率、死亡率、围手术期心肌梗死方面显著降低。对接受心脏停搏液手术的患者进行的代谢性冠状窦血液分析显示，心肌乳酸和氧摄取有良好变化。
