对具有细胞毒性活性的鼠尾草二萜和三萜类化合物的研究。

Studies on di- and triterpenoids from Salvia staminea with cytotoxic activity.

作者信息

Topcu Gulacti, Altiner Esra N, Gozcu Seyda, Halfon Belkis, Aydogmus Zeynep, Pezzuto J M, Zhou Bing-Nan, Kingston David G

出版信息

Planta Med. 2003 May;69(5):464-7. doi: 10.1055/s-2003-39705.

DOI:10.1055/s-2003-39705

PMID:12802732

Abstract

A new ursane-type triterpenoid, 3 beta,11 alpha,21 alpha-trihydroxyurs-12-ene, named salvistamineol (1), has been isolated from the methanol extract of Salvia staminea. In addition to 1, the methanol extract yielded four known compounds and the acetone extract yielded twelve known compounds consisting of two sesquiterpenes, six diterpenoids, a triterpenoid, two steroids and one flavone. DNA damaging properties of the extracts and some isolated diterpenes were investigated against three yeasts and only taxodione gave a positive response and also showed the highest cytotoxic activity against a panel of cell lines among the investigated compounds in this study.

摘要

从鼠尾草的甲醇提取物中分离出一种新的乌苏烷型三萜化合物，即3β,11α,21α-三羟基乌苏-12-烯，命名为鼠尾草胺醇（1）。除了化合物1外，甲醇提取物还得到了4种已知化合物，丙酮提取物得到了12种已知化合物，包括2种倍半萜、6种二萜、1种三萜、2种甾体和1种黄酮。研究了提取物和一些分离得到的二萜对三种酵母的DNA损伤特性，只有紫杉二酮给出了阳性反应，并且在本研究中所研究的化合物中，它对一组细胞系也表现出最高的细胞毒性活性。