Yang J-H, Luo S-D, Wang Y-S, Zhao J-F, Zhang H-B, Li L
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Graduate School of the Chinese Academy of Sciences, Kunming, Yunnan 650204, China.
J Asian Nat Prod Res. 2006 Jul-Aug;8(5):425-9. doi: 10.1080/10286020500172665.
Two new friedelane-type triterpenes, tripterfrielanons A (1) and B (2), along with six known triterpenoids, friedelin (3), canophyllal (4), canophyllalic acid (5), 3-oxo-29-hydroxyfriedelane (6), wilforlide A (7), wilforlide B (8), have been isolated from the EtOH extract of the roots of Tripterygiumwilfordii Hook.f. Compounds 4, 5, 6 were isolated for the first time from this plant. The new triterpenes 1 and 2 exhibited mild cytotoxic activity against human Hela cell lines in vitro. The assay showed the IC50 of 1 and 2 were 8.5 and 25 microg/mL, respectively.
从卫矛科植物雷公藤（Tripterygium wilfordii Hook.f.）根的乙醇提取物中分离得到两个新的木栓烷型三萜化合物雷公藤木栓烷酮A（1）和B（2），以及六个已知的三萜类化合物，分别为木栓酮（3）、香榧醛（4）、香榧酸（5）、3-氧代-29-羟基木栓烷（6）、雷公藤内酯醇A（7）、雷公藤内酯醇B（8）。化合物4、5、6首次从该植物中分离得到。新的三萜化合物1和2在体外对人宫颈癌细胞系显示出轻微的细胞毒性活性。实验表明，1和2的半数抑制浓度（IC50）分别为8.5和25微克/毫升。
