山矾中的生物活性三萜类化合物。

Bioactive triterpenoids from Symplocos chinensis.

作者信息

Li Xi-Hao, Shen Dian-Dian, Li Nan, Yu Shi-Shan

机构信息

Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.

出版信息

J Asian Nat Prod Res. 2003 Mar;5(1):49-56. doi: 10.1080/1028602031000080469.

DOI:10.1080/1028602031000080469

PMID:12608639

Abstract

A new triterpenoid, 2beta,3beta,19alpha,24-tetrahydroxy-23-norurs-12-en-28-oic acid (4), together with three known triterpenoids 3-oxo-19alpha,23,24-trihydroxyurs-12-en-28-oic acid (1), 2alpha,3beta,19alpha,23-tetrahydroxyurs-12-en-28-oic acid (2), 2alpha,3alpha,19alpha,23-tetrahydroxyurs-12-en-28-oic acid (3), was isolated from the roots of Symplocos chinensis. The new triterpenoid shows significant cytotoxic activity against B16 and BGC-823 cells.

摘要

从华山矾根中分离得到一个新的三萜类化合物，2β,3β,19α,24-四羟基-23-降乌苏-12-烯-28-酸（4），以及三个已知的三萜类化合物3-氧代-19α,23,24-三羟基乌苏-12-烯-28-酸（1）、2α,3β,19α,23-四羟基乌苏-12-烯-28-酸（2）、2α,3α,19α,23-四羟基乌苏-12-烯-28-酸（3）。该新三萜类化合物对B16和BGC-823细胞显示出显著的细胞毒活性。