Seppälä M, Julkunen M, Riittinen L, Koistinen R
Department I of Obstetrics and Gynaecology, Helsinki University Central Hospital, Finland.
Hum Reprod. 1992 Jun;7 Suppl 1:31-8. doi: 10.1093/humrep/7.suppl_1.31.
Uterine factors influence reproduction at the macro-anatomy level, and the effects of hormonal steroids on endometrial morphology are well recognized in the histopathological diagnosis of dysfunctional bleeding and infertility. During the past decade, attention has been paid to endometrial protein synthesis and secretion with respect to endocrine stimuli and implantation, and to the paracrine/autocrine effects of endometrial peptide growth factors, their binding proteins and other factors. The emphasis of this presentation is on protein secretion of the secretory endometrium, in which progesterone plays a pivotal role. Insulin-like growth factors have receptors on the endometrium, and IGF-binding proteins, stimulated by progesterone, modulate the effects of IGFs locally. Also other protein products of the secretory endometrium have been reviewed in this communication, with special emphasis on studies of a progesterone-associated endometrial protein which has many names in the literature, such as PEP, PP14, alpha 2-PEG and AUP. Extensive studies are ongoing in many laboratories to elucidate the regulation, function, interplay at tissue and cellular levels, and clinical significance of these proteins.
子宫因素在宏观解剖学水平上影响生殖，激素类固醇对子宫内膜形态的影响在功能失调性子宫出血和不孕症的组织病理学诊断中已得到充分认识。在过去十年中，人们关注了子宫内膜在内分泌刺激和着床方面的蛋白质合成与分泌，以及子宫内膜肽生长因子、它们的结合蛋白和其他因子的旁分泌/自分泌作用。本报告重点关注分泌期子宫内膜的蛋白质分泌，其中孕酮起着关键作用。胰岛素样生长因子在子宫内膜上有受体，由孕酮刺激产生的胰岛素样生长因子结合蛋白在局部调节胰岛素样生长因子的作用。此外，本通讯还综述了分泌期子宫内膜的其他蛋白质产物，特别强调了一种与孕酮相关的子宫内膜蛋白的研究，该蛋白在文献中有许多名称，如PEP、PP14、α2-PEG和AUP。许多实验室正在进行广泛研究，以阐明这些蛋白质的调节、功能、在组织和细胞水平上的相互作用以及临床意义。
