Yang Z F, Cui H W, Hasi T, Jia S Q, Gong M L, Su X L
Clinical Medicine Research Center, Inner Mongolia Medical College Affiliated Hospital, Huhhot, Inner Mongolia, China.
Genet Mol Res. 2010 Sep 14;9(3):1844-51. doi: 10.4238/vol9-3gmr938.
We examined the distribution of major allelic variants of CYP2C9 and CYP2C19 in the Mongolian population of China and compared it with that of other populations. The polymorphisms of CYP2C9 (including the CYP2C91, CYP2C92 and CYP2C93 alleles) and CYP2C19 (including the CYP2C191, CYP2C192 and CYP2C193 alleles) were analyzed in 280 healthy unrelated Chinese Mongolian subjects, using a PCR-RFLP assay. The frequencies of CYP2C9*1, *2 and 3 alleles were 0.97, 0.00 and 0.03, respectively. The frequencies of CYP2C191, *2 and *3 alleles were 0.72, 0.24 and 0.04, respectively. We did not find any differences in the allelic distribution of these two genes between age groups. However, the genotype frequency of CYP2C9 1/3 was significantly higher in males than in females. Compared with other populations, we found that the allele frequencies of the CYP2C92 and CYP2C93 allelic variants in this Mongolian population of China were similar to those reported for other Asian populations, with significant differences compared to Caucasians and African-Americans.
我们研究了中国蒙古族人群中CYP2C9和CYP2C19主要等位基因变体的分布，并将其与其他人群进行了比较。采用聚合酶链反应-限制性片段长度多态性分析方法，对280名健康、无亲缘关系的中国蒙古族受试者的CYP2C9（包括CYP2C91、CYP2C92和CYP2C93等位基因）和CYP2C19（包括CYP2C191、CYP2C192和CYP2C193等位基因）多态性进行了分析。CYP2C91、2和3等位基因的频率分别为0.97、0.00和0.03。CYP2C191、2和3等位基因的频率分别为0.72、0.24和0.04。我们未发现这两个基因的等位基因分布在各年龄组之间存在差异。然而，CYP2C9 1/3的基因型频率在男性中显著高于女性。与其他人群相比，我们发现中国蒙古族人群中CYP2C92和CYP2C93等位基因变体的频率与其他亚洲人群报道的频率相似，与白种人和非裔美国人相比存在显著差异。
