Kawano T, Kataoka H, Nagasawa H, Isogai A, Suzuki A
Department of Agricultural Chemistry, Faculty of Agriculture, University of Tokyo, Japan.
Biochem Biophys Res Commun. 1992 Nov 30;189(1):221-6. doi: 10.1016/0006-291x(92)91547-4.
We have identified the cDNAs encoding pheromone biosynthesis activating neuropeptide (PBAN) using PCR technique. The nucleotide sequence showed that the PBAN gene encodes, besides PBAN, diapause hormone and three putative amidated peptides. These four peptides share with PBAN the C-terminal pentapeptide amide which is corresponding to the shortest fragment with pheromonotropic activity. The organization of the PBAN gene is characteristic of several short neuropeptides and has some degree of similarity to that of the gene for the insect neuropeptide FMRFamide. Thus, the PBAN gene products construct a family of structurally related peptides and have various biological functions.
