Asłanowicz-Antkowiak K, Traczyk W Z
Department of Physiology, Medical University of Lodz, Poland.
J Physiol Pharmacol. 1992 Mar;43(1):89-95.
Substance P (SP) infused into the third cerebral ventricle blocks spontaneous ovulation in female rats, probably through catecholaminergic neurons. The studies presented in this paper were undertaken to investigate whether SP exerts its suppressing effect on ovulation in 6-hydroxydopamine (6-OHDA) pretreated female rats. After 8-12 days following 6-OHDA pretreatment female rats were infused, on the day of proestrus, with vehicle and all animals were found to ovulate or with a solution containing 5 nmol of SP and 89% of female rats were then found to ovulate. In the group pretreated with vehicle and subsequently infused with SP, ovulation was found to occur only in 25% of animals. The obtained results indicate that spontaneous ovulation in 6-OHDA-pretreated female rats cannot be blocked by i.c.v. administration of SP, and it may be concluded that SP exerts its suppressing effect through the monoaminergic neurons.
向第三脑室注入P物质（SP）可阻断雌性大鼠的自发排卵，这可能是通过儿茶酚胺能神经元实现的。本文所呈现的研究旨在探究SP对经6-羟基多巴胺（6-OHDA）预处理的雌性大鼠排卵是否具有抑制作用。在6-OHDA预处理8-12天后，在动情前期当天，给雌性大鼠注入赋形剂，所有动物均排卵；或者注入含5 nmol SP的溶液，随后发现89%的雌性大鼠排卵。在预先注入赋形剂并随后注入SP的组中，仅25%的动物发生排卵。所得结果表明，经6-OHDA预处理的雌性大鼠的自发排卵不能被脑室内注射SP所阻断，由此可以得出结论，SP通过单胺能神经元发挥其抑制作用。
