Jakubowska-Naziembło B, Włodzimierska B, Traczyk W Z
Acta Physiol Pol. 1980 Nov-Dec;31(6):637-45.
The purpose of the reported experiments was the study of the effects of intracerebroventricular (i.c.v.) administration of substance P (SP 1--11) and its hexapeptide C-terminal fragments SP 6--11 and (pGlu6)SP6--11 on the length of the estrus cycle. In the animals with a regular sequence of estrus aliquots of 250 pmol of the three peptides: SP 1--11, SP 6--11 and (pGlu6)SP 6--11 on the carier dextrane were infused into the left lateral cerebral ventricle through a chronically implanted cannula. For control, dextran solution in 0.9% NaCl was infused in a similar way. I.c.v. infusion of dextran in 0.9% NaCl, SP 1--11 and (pGlu6)SP 6--11 caused no significant changes in the length of the estrus cycle during which the infusion was done. Infusion of SP 6--11 prolonged the diestrus phase in most animals. This observation indicates that SP 6--11 exerted an effect on the hypothalamic mechanism controlling the secretion of gonadotropins by the hypophysis.
所报道实验的目的是研究脑室内注射P物质（SP 1-11）及其六肽C末端片段SP 6-11和（pGlu6）SP6-11对发情周期长度的影响。对于发情周期规律的动物，将250 pmol的三种肽（SP 1-11、SP 6-11和（pGlu6）SP 6-11）溶于载体右旋糖酐中，通过长期植入的套管注入左侧脑室。作为对照，以类似方式注入0.9%氯化钠中的右旋糖酐溶液。在进行输注的发情周期中，向脑室内注入0.9%氯化钠中的右旋糖酐、SP 1-11和（pGlu6）SP 6-11对发情周期长度未引起显著变化。注入SP 6-11使大多数动物的间情期延长。这一观察结果表明，SP 6-11对控制垂体促性腺激素分泌的下丘脑机制产生了影响。
