Shimasaki A K, Hirata K, Kawamura T, Kunibe N, Hirai K, Yoshimoto K, Hashimoto H, Nakahara Y, Mochizuki Y
Department of Internal Medicine, Himeji National Hospital, Japan.
Intern Med. 1992 Jul;31(7):861-5. doi: 10.2169/internalmedicine.31.861.
The level of serum granulocyte colony-stimulating factor (G-CSF) obtained from patients with leukocytosis (greater than 10,000/microliters) between May 1989 and April 1991 was measured by enzyme immunoassay. Studied were 18 patients with malignant neoplasms (median age, 64 years) and 14 patients with hematologic disease (median age, 59 years). Increased serum G-CSF values ranging from 70 to 374 pg/ml were noted in 7 of 15 lung cancer cases, a case of malignant thymoma and a blastic crisis of chronic myelogenous leukemia. The rest of the cases showed a normal value (less than 60 pg/ml). There was no correlation between the neutrophil count and G-CSF level. In lung cancer cases with high G-CSF values, neither a characteristic histologic type nor common elevation of tumor markers could be seen. The neutrophil alkaline phosphatase score was significantly increased and hypercalcemia was presented in high G-CSF cases. G-CSF may contribute at least in part to unknown leukocytosis observed in malignant neoplasms, especially in lung cancer.
采用酶免疫分析法测定了1989年5月至1991年4月白细胞增多症（大于10,000/微升）患者的血清粒细胞集落刺激因子（G-CSF）水平。研究对象为18例恶性肿瘤患者（中位年龄64岁）和14例血液系统疾病患者（中位年龄59岁）。在15例肺癌患者中的7例、1例恶性胸腺瘤患者和1例慢性粒细胞白血病急变期患者中，观察到血清G-CSF值升高，范围为70至374 pg/ml。其余病例显示正常数值（小于60 pg/ml）。中性粒细胞计数与G-CSF水平之间无相关性。在G-CSF值高的肺癌病例中，既未观察到特征性组织学类型，也未发现肿瘤标志物普遍升高。G-CSF值高的病例中性粒细胞碱性磷酸酶评分显著升高且出现高钙血症。G-CSF可能至少部分导致了恶性肿瘤尤其是肺癌中出现的不明原因白细胞增多。
