Division of Thoracic Oncology, Shizuoka Cancer Center, 1007 Shimonagakubo Nagaizumi-cho, Shizuoka 411-8777, Japan.
Int J Clin Oncol. 2009 Dec;14(6):534-6. doi: 10.1007/s10147-009-0875-6. Epub 2009 Dec 5.
Granulocyte colony-stimulating factor (G-CSF)-producing thymic carcinoma is extremely rare. A-66-year-old man presented with an anterior mediastinal mass, and underwent surgical biopsy. He had marked leukocytosis, and his serum levels of G-CSF and interleukin-6 were elevated. Histologically, the tumor consisted of squamous cell carcinoma, which showed positive immunoreactivity for G-CSF. He was treated with thoracic radiotherapy, and chest imaging revealed a marked reduction of tumor size. He was doing well at 8 months after tumor diagnosis.
粒细胞集落刺激因子（G-CSF）产生的胸腺癌极为罕见。一名 66 岁男性因前纵隔肿块就诊，并接受了手术活检。他白细胞显著增多，血清 G-CSF 和白细胞介素 6 水平升高。组织学上，肿瘤由鳞状细胞癌组成，G-CSF 免疫反应阳性。他接受了胸部放疗，胸部影像学显示肿瘤明显缩小。在肿瘤诊断 8 个月后，他恢复良好。
