Henderson M G, Fuller R W
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285.
Brain Res. 1992 Oct 30;594(2):323-6. doi: 10.1016/0006-8993(92)91144-4.
A role for calcium in p-chloroamphetamine-induced neurotoxicity has been inferred previously from protective effects of dextromethorphan. We found that dextromethorphan reduces rat brain concentrations of 5-hydroxyindoleacetic acid and blocks the acute, non-neurotoxic depletion of brain serotonin by p-chloroamphetamine and by H75/12. Inhibition of the membrane transporter on brain serotonin neurons by dextromethorphan in vivo might explain its protective effect against p-chloroamphetamine neurotoxicity.
先前已从右美沙芬的保护作用推断出钙在对氯苯丙胺诱导的神经毒性中所起的作用。我们发现右美沙芬可降低大鼠脑内5-羟吲哚乙酸的浓度，并能阻断对氯苯丙胺和H75/12引起的脑血清素的急性非神经毒性耗竭。右美沙芬在体内对脑血清素神经元膜转运体的抑制作用可能解释了其对氯苯丙胺神经毒性的保护作用。
