Finnegan K T, Kerr J T, Langston J W
Department of Psychiatry, University of Utah School of Medicine, Salt Lake City.
Brain Res. 1991 Aug 30;558(1):109-11. doi: 10.1016/0006-8993(91)90723-9.
Dextromethorphan, an agent that blocks the neuronal-damaging effects of hypoxemia in vitro, was tested for its ability to prevent the neurotoxic effects of p-chloroamphetamine (PCA). Rats were treated with either saline, PCA, dextromethorphan, or the combination of PCA and increasing doses of dextromethorphan. Dextromethorphan provided a dose-related protection against the serotonin (5-HT)-depleting effects of PCA. These observations may offer a clue as to the mechanism responsible for PCA-induced neurotoxicity.
右美沙芬是一种在体外可阻断低氧血症对神经元损伤作用的药物，现对其预防对氯苯丙胺（PCA）神经毒性作用的能力进行了测试。给大鼠分别注射生理盐水、PCA、右美沙芬，或PCA与递增剂量右美沙芬的组合。右美沙芬对PCA引起的血清素（5-HT）消耗效应具有剂量相关的保护作用。这些观察结果可能为PCA诱导神经毒性的机制提供线索。
