Kunapuli Satva P
Department of Physiology, and the Sol Sherry Thrombosis Research Center, Temple University Medical School, Philadelphia, PA 19140, USA.
ScientificWorldJournal. 2002 Feb 13;2:424-33. doi: 10.1100/tsw.2002.106.
Adenosine diphosphate (ADP) plays a crucial role in hemostasis and thrombosis by activating platelets. In platelets, the classical P2T receptor is now resolved into three P2 receptor subtypes: the P2Y1, the P2Y12, and the P2X1 receptors. Both pharmacological and molecular biological approaches have confirmed the role of the P2Y1 and P2Y12 receptors in the ADP-induced platelet fibrinogen receptor activation. The P2Y1 and the P2X1 receptors independently contribute to platelet shape change. Whereas the P2Y12 receptor mediates the potentiation of dense granule release reaction, both the P2Y1 and P2Y12 receptors play an important role in the ADP-induced phospholipase A2 activation. The signaling events downstream of these receptors leading to the physiological effects remain elusive, and they are yet to be delineated.
二磷酸腺苷（ADP）通过激活血小板在止血和血栓形成中发挥关键作用。在血小板中，经典的P2T受体现已解析为三种P2受体亚型：P2Y1、P2Y12和P2X1受体。药理学和分子生物学方法均已证实P2Y1和P2Y12受体在ADP诱导的血小板纤维蛋白原受体激活中的作用。P2Y1和P2X1受体分别促成血小板形状改变。而P2Y12受体介导致密颗粒释放反应的增强，P2Y1和P2Y12受体在ADP诱导的磷脂酶A2激活中均起重要作用。这些受体下游导致生理效应的信号事件仍不清楚，有待阐明。
