Nagao Keiichi
Health Sciences Center, Chiba University.
Nihon Rinsho. 2003 Jun;61(6):990-4.
Pulmonary toxicities, with special reference to interstitial pneumonia, due to cancer chemotherapy and/or chest irradiation were reviewed. Two sorts of mechanism of development of the interstitial pneumonia are considered; one is directly cytotoxic action to pneumocytes and/or pulmonary capillary endothelium and the other is an allergic mechanism against anticancer drug or its derivatives. The risk factors of cancer therapy induced interstitial pneumonia are an aged, poor performance status, and underlying interstitial pulmonary diseases. Recently some new serum markers involving KL-6 for interstitial pneumonia have been reported and further studies are needed to clarify whether these markers are predictive of subsequent pulmonary damage by anti-cancer treatments.
对癌症化疗和/或胸部放疗引起的肺部毒性，尤其是间质性肺炎进行了综述。间质性肺炎的发生机制有两种；一种是对肺细胞和/或肺毛细血管内皮的直接细胞毒性作用，另一种是对抗癌药物或其衍生物的过敏机制。癌症治疗引起的间质性肺炎的危险因素包括年龄较大、身体状况较差和潜在的间质性肺部疾病。最近有一些涉及KL-6的间质性肺炎新血清标志物的报道，需要进一步研究以明确这些标志物是否能预测后续抗癌治疗对肺部的损害。
