• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Mechanisms of troglitazone hepatotoxicity.

作者信息

Smith Martyn T

机构信息

Division of Environmental Health Sciences, School of Public Health, University of California at Berkeley, Berkeley, California 94720-7360, USA.

出版信息

Chem Res Toxicol. 2003 Jun;16(6):679-87. doi: 10.1021/tx034033e.

DOI:10.1021/tx034033e
PMID:12807350
Abstract
摘要

相似文献

1
Mechanisms of troglitazone hepatotoxicity.曲格列酮肝毒性的机制。
Chem Res Toxicol. 2003 Jun;16(6):679-87. doi: 10.1021/tx034033e.
2
Application of systems pharmacology to explore mechanisms of hepatotoxicity.应用系统药理学探索肝毒性机制。
Clin Pharmacol Ther. 2014 Nov;96(5):536-7. doi: 10.1038/clpt.2014.167.
3
Troglitazone hepatotoxicity: are we getting closer to understanding idiosyncratic liver injury?曲格列酮肝毒性:我们离理解特异质性肝损伤更近了吗?
Toxicol Sci. 2007 May;97(1):1-3. doi: 10.1093/toxsci/kfm021.
4
Involvement of organic anion transporting polypeptides in the transport of troglitazone sulfate: implications for understanding troglitazone hepatotoxicity.有机阴离子转运多肽参与硫酸曲格列酮的转运:对理解曲格列酮肝毒性的意义。
Drug Metab Dispos. 2004 Mar;32(3):291-4. doi: 10.1124/dmd.32.3.291.
5
Troglitazone-induced hepatic necrosis in an animal model of silent genetic mitochondrial abnormalities.曲格列酮在隐匿性遗传性线粒体异常动物模型中诱导肝坏死。
Toxicol Sci. 2007 May;97(1):205-13. doi: 10.1093/toxsci/kfl180. Epub 2006 Dec 5.
6
Systems pharmacology modeling predicts delayed presentation and species differences in bile acid-mediated troglitazone hepatotoxicity.系统药理学建模预测了胆汁酸介导的曲格列酮肝毒性中的延迟表现和物种差异。
Clin Pharmacol Ther. 2014 Nov;96(5):589-98. doi: 10.1038/clpt.2014.158. Epub 2014 Jul 28.
7
Two cases of severe clinical and histologic hepatotoxicity associated with troglitazone.
Ann Intern Med. 1998 Jul 1;129(1):36-8. doi: 10.7326/0003-4819-129-1-199807010-00008.
8
Metabolic flux profiling of reaction modules in liver drug transformation.
Pac Symp Biocomput. 2007:193-204.
9
Increased susceptibility to troglitazone-induced mitochondrial permeability transition in type 2 diabetes mellitus model rat.2型糖尿病模型大鼠对曲格列酮诱导的线粒体通透性转换的易感性增加。
J Toxicol Sci. 2018;43(5):339-351. doi: 10.2131/jts.43.339.
10
Prediction of drug-induced immune-mediated hepatotoxicity using hepatocyte-like cells derived from human embryonic stem cells.利用源自人类胚胎干细胞的类肝细胞预测药物诱导的免疫介导性肝毒性。
Toxicology. 2017 Jul 15;387:1-9. doi: 10.1016/j.tox.2017.06.005. Epub 2017 Jun 20.

引用本文的文献

1
Periodontal ligament fibroblasts utilize isoprenoid intermediate farnesyl diphosphate for maintaining osteo/cementogenic differentiation abilities.牙周膜成纤维细胞利用类异戊二烯中间体法呢基二磷酸来维持骨/牙骨质生成分化能力。
J Dent Sci. 2025 Jan;20(1):560-568. doi: 10.1016/j.jds.2024.04.025. Epub 2024 May 3.
2
Increasing sustainability and reproducibility of toxicology applications: serum-free cultivation of HepG2 cells.提高毒理学应用的可持续性和可重复性:HepG2细胞的无血清培养
Front Toxicol. 2024 Nov 22;6:1439031. doi: 10.3389/ftox.2024.1439031. eCollection 2024.
3
Development of a Novel In Silico Classification Model to Assess Reactive Metabolite Formation in the Cysteine Trapping Assay and Investigation of Important Substructures.
新型计算机分类模型的建立用于评估半胱氨酸捕集试验中反应代谢产物的形成,并研究重要的亚结构。
Biomolecules. 2024 Apr 30;14(5):535. doi: 10.3390/biom14050535.
4
Metabolites in the regulatory risk assessment of pesticides in the EU.欧盟农药监管风险评估中的代谢物
Front Toxicol. 2023 Dec 19;5:1304885. doi: 10.3389/ftox.2023.1304885. eCollection 2023.
5
A systems approach reveals species differences in hepatic stress response capacity.系统方法揭示了肝脏应激反应能力的种间差异。
Toxicol Sci. 2023 Oct 30;196(1):112-125. doi: 10.1093/toxsci/kfad085.
6
Metabolomics-based strategy to assess drug hepatotoxicity and uncover the mechanisms of hepatotoxicity involved.基于代谢组学的策略来评估药物肝毒性,并揭示涉及的肝毒性机制。
Arch Toxicol. 2023 Jun;97(6):1723-1738. doi: 10.1007/s00204-023-03474-8. Epub 2023 Apr 6.
7
Analysis of reproducibility and robustness of OrganoPlate® 2-lane 96, a liver microphysiological system for studies of pharmacokinetics and toxicological assessment of drugs.分析 OrganoPlate® 2 道 96 孔板,一种用于研究药物药代动力学和毒理学评估的肝脏微生理系统的重现性和稳健性。
Toxicol In Vitro. 2022 Dec;85:105464. doi: 10.1016/j.tiv.2022.105464. Epub 2022 Aug 31.
8
Pre-clinical 2D and 3D toxicity response to a panel of nanomaterials; comparative assessment of NBM-induced liver toxicity.对一组纳米材料的临床前 2D 和 3D 毒性反应;NBM 诱导的肝毒性的比较评估。
Drug Deliv Transl Res. 2022 Sep;12(9):2157-2177. doi: 10.1007/s13346-022-01170-1. Epub 2022 Jun 28.
9
Current Perspective: 3D Spheroid Models Utilizing Human-Based Cells for Investigating Metabolism-Dependent Drug-Induced Liver Injury.当前视角:利用人源细胞的3D球体模型研究代谢依赖性药物性肝损伤
Front Med Technol. 2020 Nov 30;2:611913. doi: 10.3389/fmedt.2020.611913. eCollection 2020.
10
Key Characteristics of Human Hepatotoxicants as a Basis for Identification and Characterization of the Causes of Liver Toxicity.人用肝毒物的关键特征作为鉴定和描述肝毒性原因的基础。
Hepatology. 2021 Dec;74(6):3486-3496. doi: 10.1002/hep.31999. Epub 2021 Jul 13.