Versteeg Henri H, Peppelenbosch Maikel P, Spek C Arnold
Laboratory for Experimental Internal Medicine, G2-130, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
Carcinogenesis. 2003 Jun;24(6):1009-13. doi: 10.1093/carcin/bgg039. Epub 2003 Mar 28.
Tissue factor (TF), a 47-kDa transmembrane glycoprotein, is a principal regulator of oncogenic neoangiogenesis and controls therefore the cancerous process. Although originally identified as a component of the coagulation cascade, it has become clear that TF functions as a cytokine-like receptor and this notion was confirmed by the discovery of coagulation-independent actions of TF (which include regulation of tumour growth, embryonic and oncogenic blood vessel formation as well as regulation of inflammation and sepsis). In accordance, TF-mediated signal transduction events are readily detected and the elucidation of the underlying molecular mechanisms has recently seen spectacular progress and it is now understood that the role of TF in angiogenesis is both coagulation-dependent and independent. The recent evidence for this emerging insight will be the subject of this review.
组织因子（TF）是一种47 kDa的跨膜糖蛋白，是致癌性新血管生成的主要调节因子，因此控制着癌症进程。尽管最初被鉴定为凝血级联反应的一个组成部分，但现在已经明确TF作为一种细胞因子样受体发挥作用，TF的非凝血依赖性作用（包括肿瘤生长调节、胚胎和致癌性血管形成以及炎症和脓毒症调节）的发现证实了这一概念。相应地，TF介导的信号转导事件很容易被检测到，并且对潜在分子机制的阐明最近取得了显著进展，现在人们认识到TF在血管生成中的作用既是凝血依赖性的也是非凝血依赖性的。这一新兴见解的最新证据将是本综述的主题。
