复杂疾病连锁与关联基因组筛查中的错误发现率
False discovery rate in linkage and association genome screens for complex disorders.
作者信息
Sabatti Chiara, Service Susan, Freimer Nelson
机构信息
Department of Human Genetics and Statistics, University of California, Los Angeles 90095-7088, USA.
出版信息
Genetics. 2003 Jun;164(2):829-33. doi: 10.1093/genetics/164.2.829.
Abstract
We explore the implications of the false discovery rate (FDR) controlling procedure in disease gene mapping. With the aid of simulations, we show how, under models commonly used, the simple step-down procedure introduced by Benjamini and Hochberg controls the FDR for the dependent tests on which linkage and association genome screens are based. This adaptive multiple comparison procedure may offer an important tool for mapping susceptibility genes for complex diseases.
摘要
我们探讨了错误发现率（FDR）控制程序在疾病基因定位中的意义。借助模拟，我们展示了在常用模型下，本雅明尼和霍奇伯格提出的简单逐步下调程序如何控制连锁和关联基因组筛选所基于的相关检验的FDR。这种适应性多重比较程序可能为复杂疾病的易感基因定位提供一个重要工具。
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