Baker Stuart N, Curio Gabriel, Lemon Roger N
Department of Anatomy, University of Cambridge, Cambridge CB2 3DY, UK.
J Physiol. 2003 Jul 15;550(Pt 2):529-34. doi: 10.1113/jphysiol.2003.045674. Epub 2003 Jun 13.
The human electroencephalogram (EEG) is generated predominantly by synchronised cortical excitatory postsynaptic potentials oscillating at frequencies <100 Hz. Unusually, EEG responses to electrical nerve stimulation contain brief bursts of high-frequency (600 Hz) wavelets. Here we show, in awake monkeys, that a subset of primary somatosensory cortex single units consistently fires both bursts and single spikes phase-locked to EEG wavelets. Spike bursts were also evoked by tactile stimuli, proving that this is a natural response mode. EEG wavelets at 600 Hz may therefore permit non-invasive assessment of population spike timing in human cortex.
人类脑电图（EEG）主要由频率低于100Hz的同步皮质兴奋性突触后电位产生。不同寻常的是，EEG对电神经刺激的反应包含高频（600Hz）小波的短暂爆发。在这里，我们在清醒的猴子身上发现，初级体感皮层的一部分单个神经元持续发放与EEG小波锁相的爆发性放电和单个尖峰。触觉刺激也能诱发爆发性放电，证明这是一种自然反应模式。因此，600Hz的EEG小波可能允许对人类皮层群体尖峰时间进行无创评估。
