Manjarrez M E, Rosete D P, Rincón M, Villalba J, Cravioto A, Cabrera R
Departamento de Investigación en Virología, Instituto Nacional de Enfermedades Respiratorias (INER), México DF 14080, Mexico 2Departamento de Salud Pública, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), México DF 04510, Mexico.
J Med Microbiol. 2003 Jul;52(Pt 7):579-583. doi: 10.1099/jmm.0.05007-0.
In Mexico, there is a lack of up-to-date published data that show viruses to be the main cause of acute respiratory infection (ARI). The objective of this study was to estimate the comparative viral frequency between children under the age of 5 years with and without ARI (n = 179 in each group) in a suburban community (Nezahualcóyotl City). A nasopharyngeal sample was collected for viral culture and identification was carried out by indirect immunofluorescence (IIF) using mAbs. There were no sex differences between the two groups. Children under 1 year of age with ARI showed a higher frequency (56 %) of viral infections; this was statistically significant (P < 0.05) when compared with the same age group in ARI-free children (17 %). Respiratory syncytial virus (RSV) was the most prevalent type of virus isolated from both groups (38 vs 18 %). A statistically significantly higher number of subjects with ARI (33/179) than without (12/179) were infected with RSV (P < 0.003). Prevalences of four other viruses studied were similar in the two groups. The highest viral incidence of ARI in children was detected in the winter-spring seasonal period.
在墨西哥，缺乏最新的已发表数据表明病毒是急性呼吸道感染（ARI）的主要病因。本研究的目的是估计在一个郊区社区（内萨瓦尔科约特尔市）中，5岁以下患ARI和未患ARI的儿童（每组n = 179）之间的病毒相对感染率。采集鼻咽样本进行病毒培养，并使用单克隆抗体通过间接免疫荧光法（IIF）进行鉴定。两组之间不存在性别差异。1岁以下患ARI的儿童病毒感染率更高（56%）；与同年龄组未患ARI的儿童（17%）相比，这具有统计学意义（P < 0.05）。呼吸道合胞病毒（RSV）是两组中分离出的最常见病毒类型（38%对18%）。患ARI的受试者（33/179）感染RSV的人数在统计学上显著高于未患ARI的受试者（12/179）（P < 0.003）。研究的其他四种病毒的感染率在两组中相似。儿童ARI的病毒感染率在冬春季节最高。
