Köbel F, Dorazilová V, Kümmel L
Recent Adv Stud Cardiac Struct Metab. 1975;6:431-6.
The microscopic structure of left ventricular wall aneurysms and akinetic zones differs markedly. In samples obtained from akinetic zones, dystrophic changes and marked hypertrophy of muscle cells were observed with dispersed myofibrosis. In 1 case of left ventricular wall aneurysm, a pronounced nonspecific inflammatory reaction in the subepicardial layer was present. In all samples investigated, there were marked morphological signs of activated proteosynthesis, mainly aggregations of ribosomes, both in the muscle cells and in the fibroblasts. Utilization of glucose-14C was highest in samples with a predominant content of muscle cells. Pentose-phosphate shunt activity was highest in samples consisting mainly of fibrous scar tissue. The ability of the tissue homogenate to incorporate glycine-14C into the trichloracetic acid-precipitated protein was higher in samples containing predominantly connective tissue. The highest activity of the pentose-phosphate shunt, together with the highest rate of proteosynthesis, was observed in the sample from the left ventricular wall aneurysm with marked inflammatory infiltration of the tissue.
左心室壁动脉瘤和运动不能区的微观结构明显不同。在取自运动不能区的样本中，观察到肌营养不良变化和肌细胞明显肥大，伴有散在性肌纤维纤维化。在1例左心室壁动脉瘤中，心外膜下层存在明显的非特异性炎症反应。在所有研究样本中，无论是肌细胞还是成纤维细胞，均有明显的蛋白质合成激活的形态学迹象，主要是核糖体聚集。在肌细胞含量占主导的样本中，葡萄糖-14C的利用率最高。磷酸戊糖途径活性在主要由纤维瘢痕组织组成的样本中最高。在主要含结缔组织的样本中，组织匀浆将甘氨酸-14C掺入三氯乙酸沉淀蛋白的能力更高。在组织有明显炎症浸润的左心室壁动脉瘤样本中，观察到磷酸戊糖途径的活性最高，同时蛋白质合成速率也最高。
