Ignat'ev G M, Tazulakhova E B, Borsuk E A, Morozov N S, Razvorotnev V A, Vorob'eva M S
Antibiot Khimioter. 1992 Jul;37(7):28-31.
Combined use of vaccine and immunomodulators such as ridostin, inosiplex and polyribonate against acute encephalomyelitis of humans (AEMHs) was studied. It was shown that low immunogenic doses of the vaccine did not provide a protective action against the virus of AEMHs while after administration of the vaccine in combination with the immunomodulators there was protection in all the groups of the animals exposed to the low immunogenic doses of the vaccine during the first immunization. It was noted in regard to all the combinations of the immunomodulators and vaccine used in the low immunogenic doses that the level of the increase in the titer of the virus-specific antibodies, the proliferative activity to the specific antigen and mitogens and of interferon induction depended on the immunomodulator type. At the same time, it was found that the marked production of interferon within the first 24 hours observed after the use of the combination of inosiplex, ridostin and the vaccine resulted in increased activity of natural killer cells and lower proliferative activity of cells and production of virus-specific antibodies. This was indicative of the necessity of choosing the immunomodulators, their doses and time of the administration in relation to the immunization.
研究了疫苗与诸如瑞多斯汀、肌苷肽和聚核糖核苷酸等免疫调节剂联合使用对抗人类急性脑脊髓炎（AEMHs）的效果。结果表明，低免疫原性剂量的疫苗对AEMHs病毒没有保护作用，而在疫苗与免疫调节剂联合给药后，在首次免疫期间接受低免疫原性剂量疫苗的所有动物组中均出现了保护作用。关于低免疫原性剂量使用的免疫调节剂与疫苗的所有组合，发现病毒特异性抗体滴度的升高水平、对特异性抗原和有丝分裂原的增殖活性以及干扰素诱导水平取决于免疫调节剂的类型。同时，发现使用肌苷肽、瑞多斯汀和疫苗组合后在最初24小时内观察到的显著干扰素产生导致自然杀伤细胞活性增加，细胞增殖活性降低以及病毒特异性抗体产生减少。这表明有必要根据免疫接种情况选择免疫调节剂、其剂量和给药时间。
