Bulychev L E, Sergeeva A N, Ryzhikov A B, Kotliarov L A, Poryvaev V D, Pliasunov I V
Antibiot Khimioter. 1995 May;40(5):28-31.
The investigation of the prevention and treatment action of some immunomodulators (ridostin, reaferon and polyribonate) used alone and in combinations was conducted on laboratory animals infected aerogenically by Venezuelan equine encephalitis (VEE) virus. A lower death rate of the aerogenically infected mice (10-30 respiratory LD50) was observed after intramuscular injection of ridostin. The preventive affect of ridostin and ridostin + reaferon administered intranasally and intramuscularly was achieved in the aerogenically infected guinea pigs (10 respiratory LD50). The results of the study on the early virus reproduction in the animals were used for the choice of the treatment scheme. The immunomodulators had no effect when the treatment was started 1 day after the VEE virus infection.
对单独使用及联合使用某些免疫调节剂（利度司亭、重组干扰素α-2b和聚肌胞苷酸）预防和治疗委内瑞拉马脑炎（VEE）病毒气溶胶感染实验动物的作用进行了研究。肌肉注射利度司亭后，观察到气溶胶感染小鼠（10 - 30个呼吸道半数致死剂量）的死亡率降低。对气溶胶感染的豚鼠（10个呼吸道半数致死剂量）经鼻内和肌肉注射利度司亭以及利度司亭+重组干扰素α-2b可起到预防作用。对动物早期病毒繁殖的研究结果用于治疗方案的选择。在VEE病毒感染1天后开始治疗时，免疫调节剂没有效果。
