转化生长因子-β（TGF-β）从细胞膜到细胞核的信号传导机制。

Mechanisms of TGF-beta signaling from cell membrane to the nucleus.

作者信息

Shi Yigong, Massagué Joan

机构信息

Department of Molecular Biology, Princeton University, Washington Road, Princeton, NJ 08544, USA.

出版信息

Cell. 2003 Jun 13;113(6):685-700. doi: 10.1016/s0092-8674(03)00432-x.

DOI:10.1016/s0092-8674(03)00432-x

PMID:12809600

Abstract

TGF-beta signaling controls a plethora of cellular responses and figures prominently in animal development. Recent cellular, biochemical, and structural studies have revealed significant insight into the mechanisms of the activation of TGF-beta receptors through ligand binding, the activation of Smad proteins through phosphorylation, the transcriptional regulation of target gene expression, and the control of Smad protein activity and degradation. This article reviews these latest advances and presents our current understanding on the mechanisms of TGF-beta signaling from cell membrane to the nucleus.

摘要

转化生长因子-β（TGF-β）信号传导控制着众多细胞反应，在动物发育过程中起着重要作用。最近的细胞、生化和结构研究对TGF-β受体通过配体结合激活的机制、Smad蛋白通过磷酸化激活的机制、靶基因表达的转录调控以及Smad蛋白活性和降解的控制有了深入了解。本文综述了这些最新进展，并阐述了我们目前对TGF-β信号从细胞膜到细胞核的传导机制的理解。