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多孔羟基磷灰石支架的电泳沉积

Electrophoretic deposition of porous hydroxyapatite scaffold.

作者信息

Ma J, Wang C, Peng K W

机构信息

School of Materials Engineering, Nanyang Technological University, Nanyang Avenue 639798, Singapore.

出版信息

Biomaterials. 2003 Sep;24(20):3505-10. doi: 10.1016/s0142-9612(03)00203-5.

Abstract

Bioactive porous hydroxyapatite (HA) scaffold was fabricated using electrophoretic deposition (EPD) technique in the present work. Bulk HA scaffold was achieved by repeated deposition. The green scaffold was sintered at 1200 degrees C to 82% of the theoretical density. Scanning electron microscopy examination and mercury porosimetry measurement have shown that the porosity remains interconnected and a range of pore size from several microns to hundreds of microns was obtained. X-ray diffraction analysis was performed and confirmed that there is no HA decomposition during the sintering process. Mechanical characterization has also shown that the EPD scaffold possesses excellent properties. Cell culturing experiment was carried out and the result shows that the scaffold bioactivity is not only dependent on the interconnectivity of the pores, but also the pore size.

摘要

在本工作中,采用电泳沉积(EPD)技术制备了生物活性多孔羟基磷灰石(HA)支架。通过重复沉积获得块状HA支架。将绿色支架在1200℃下烧结至理论密度的82%。扫描电子显微镜检查和压汞法测量表明,孔隙率保持相互连通,获得了从几微米到数百微米的一系列孔径。进行了X射线衍射分析,证实烧结过程中没有HA分解。力学表征还表明,EPD支架具有优异的性能。进行了细胞培养实验,结果表明支架的生物活性不仅取决于孔隙的连通性,还取决于孔径。

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