Hsu Y H, Turner I G, Miles A W
Centre for Orthopaedic Biomechanics, Department of Mechanical Engineering, University of Bath, Claverton Down, Bath BA2 7AY, UK.
J Mater Sci Mater Med. 2007 Dec;18(12):2319-29. doi: 10.1007/s10856-007-3136-0. Epub 2007 Jun 14.
Porous hydroxyapatite/tricalcium phosphate (HA/TCP) bioceramics were fabricated by a novel technique of vacuum impregnation of reticulated polymeric foams with ceramic slip. The samples had approximately 5-10% interconnected porosity and controlled pore sizes appropriate to allow bone ingrowth, combined with good mechanical properties. A range of polyurethane foams with 20, 30 and 45 pores per inch (ppi) were used as templates to produce samples for testing. The foams were inpregnated with solid loadings in the range of 60-140 wt%. The results indicated that the average apparent density of the HA/TCP samples was 2.48 g/cm(3), the four-point bending strength averaged 16.98 MPa, the work of fracture averaged 15.46 J/m(2) and the average compressive strength was 105.56 MPa. A range of mechanical properties resulted from the various combinations of different grades of PU foam and the solid loading of slips. The results indicated that it is possible to manufacture open pore HA/TCP bioceramics, with compressive strengths comparable to human bone, which could be of significant clinical interest.
多孔羟基磷灰石/磷酸三钙（HA/TCP）生物陶瓷是通过一种用陶瓷浆料真空浸渍网状聚合物泡沫的新技术制造的。这些样品具有约5-10%的相互连通孔隙率以及适合骨长入的可控孔径，同时具备良好的机械性能。使用一系列每英寸分别有20、30和45个孔（ppi）的聚氨酯泡沫作为模板来制备用于测试的样品。这些泡沫用60-140 wt%范围内的固体负载量进行浸渍。结果表明，HA/TCP样品的平均表观密度为2.48 g/cm³，四点弯曲强度平均为16.98 MPa，断裂功平均为15.46 J/m²，平均抗压强度为105.56 MPa。不同等级的聚氨酯泡沫和浆料的固体负载量的各种组合产生了一系列机械性能。结果表明，有可能制造出抗压强度与人骨相当的开孔HA/TCP生物陶瓷，这可能具有重大的临床意义。
