Toll样白细胞介素-1受体衔接蛋白家族成员增至五个。
The Toll-IL-1 receptor adaptor family grows to five members.
作者信息
O'Neill Luke A J, Fitzgerald Katherine A, Bowie Andrew G
机构信息
Cytokine Research Group, Department of Biochemistry, Trinity College, Dublin, Ireland.
出版信息
Trends Immunol. 2003 Jun;24(6):286-90. doi: 10.1016/s1471-4906(03)00115-7.
Toll-like receptor (TLR) signal transduction is mediated by an adaptor protein termed MyD88. In the case of TLR2 and TLR4, another adaptor related to MyD88 called Mal also participates in signalling. Two recent papers have added a third adaptor to the family, called Toll-interleukin-1 receptor (TIR) domain-containing adaptor inducing interferon-beta (IFN-beta) (TRIF) or TIR-containing adaptor molecule-1 (TICAM-1), which is particularly important for IFN regulatory factor-3 (IRF-3) activation by antiviral TLR3. Two additional adaptors are present in humans, termed Trif-related adaptor molecule (TRAM) and sterile alpha and HEAT-Armadillo motifs (SARM). It is probable that differential use of adaptors will help explain the distinct pathways activated by TLRs during host defence.
Toll样受体（TLR）信号转导由一种名为髓样分化因子88（MyD88）的接头蛋白介导。就TLR2和TLR4而言，另一种与MyD88相关的接头蛋白Mal也参与信号传导。最近的两篇论文在该家族中增加了第三种接头蛋白，称为含Toll样受体白细胞介素1受体（TIR）结构域的接头蛋白，可诱导干扰素-β（IFN-β）（TRIF）或含TIR的接头分子1（TICAM-1）, 这对于抗病毒TLR3激活干扰素调节因子3（IRF-3）尤为重要。人类中还存在另外两种接头蛋白，分别称为TRIF相关接头分子（TRAM）和无菌α及热重复-犰狳基序（SARM）。接头蛋白的差异使用可能有助于解释宿主防御过程中TLR激活不同的信号通路。
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