Ichida T, Kato M, Hayakawa A, Watanabe M, Igarashi K, Hata K, Doya Y, Miura M, Sato H, Asakura H
Third Department of Internal Medicine, Niigata University School of Medicine, Japan.
Cancer Chemother Pharmacol. 1992;31 Suppl:S51-4. doi: 10.1007/BF00687105.
Lipiodol injection is a useful method for detecting liver tumors, especially hepatocellular carcinoma (HCC). We therefore prepared and tested a new emulsion of lipiodol containing epirubicin and cis-diammine-dichloroplatinum (CDDP), drugs that are very effective against HCC. This CDDP-epirubicin-lipiodol suspension (CELS) was injected into 18 HCC patients via a celiac angiographic catheter. In 11 of these patients, CELS was followed by transcatheter arterial embolization (TAE) therapy. Clinical and pharmacological investigations were performed in all 18 patients, and the following results were obtained. CELS is pharmacologically and chemically stable, and both the results of the dissolution test and the serum levels of these two drugs indicate that slow release can be obtained. After the injection of CELS, serum levels of AFP and PIVKA-II decreased immediately, and no fatal clinical side effects were encountered. Although no statistically significant difference was observed, the survival (Kaplan-Meier method) of patients injected with CELS in the presence or absence of TAE therapy can be estimated to be much longer than that of patients receiving CDDP-lipiodol suspension injection in the presence (16 patients) or absence (6 patients) of TAE therapy. A combination of CELS injection and TAE therapy might be effective and useful for the treatment of HCC.
碘油注射是检测肝脏肿瘤，尤其是肝细胞癌（HCC）的一种有用方法。因此，我们制备并测试了一种含表柔比星和顺二氯二氨铂（CDDP）的新型碘油乳剂，这两种药物对HCC非常有效。将这种顺铂-表柔比星-碘油混悬液（CELS）通过腹腔血管造影导管注入18例HCC患者体内。其中11例患者在注入CELS后接受了经导管动脉栓塞（TAE）治疗。对所有18例患者进行了临床和药理学研究，获得了以下结果。CELS在药理和化学上是稳定的，溶出度试验结果和这两种药物的血清水平均表明可以实现缓释。注入CELS后，甲胎蛋白（AFP）和异常凝血酶原-II（PIVKA-II）的血清水平立即下降，且未出现致命的临床副作用。尽管未观察到统计学上的显著差异，但接受或未接受TAE治疗的注入CELS的患者的生存期（Kaplan-Meier法）估计比接受或未接受TAE治疗（分别为16例和6例）的接受顺铂-碘油混悬液注射的患者长得多。CELS注射与TAE治疗相结合可能对HCC的治疗有效且有用。
