DeFranco A L
Department of Microbiology and Immunology, University of California, San Francisco 94143-0552.
Eur J Biochem. 1992 Dec 1;210(2):381-8. doi: 10.1111/j.1432-1033.1992.tb17432.x.
Lymphocytes provide a powerful defense against infectious agents with their exquisite ability to distinguish between macromolecules of the host and macromolecules of foreign invaders. This ability derives from the antigen receptors, which are created from precursor minigenes by a series of genetic-recombination reactions [1, 2] and from cellular mechanisms that inactivate lymphocytes expressing self-reactive antigen receptors [3, 4]. Central to the problem of distinguishing self from non-self is the means by which these antigen receptors recognize antigen and transmit the information of that recognition to the interior of the cell. This information ultimately leads to lymphocyte activation or inactivation, depending upon the context. In this review, I shall summarize recent advances in understanding the structural elements of the antigen receptor complex of B lymphocytes and in understanding the signal-transduction events initiated by this receptor.
淋巴细胞凭借其卓越的能力，能够区分宿主的大分子和外来入侵者的大分子，从而为抵御感染因子提供强大的防御。这种能力源于抗原受体，抗原受体是由前体小基因通过一系列基因重组反应产生的[1,2]，也源于使表达自身反应性抗原受体的淋巴细胞失活的细胞机制[3,4]。区分自身与非自身问题的核心在于这些抗原受体识别抗原并将识别信息传递到细胞内部的方式。根据具体情况，这些信息最终会导致淋巴细胞激活或失活。在这篇综述中，我将总结在理解B淋巴细胞抗原受体复合物的结构元件以及理解该受体引发的信号转导事件方面的最新进展。
