Raether W, Hänel H
Aventis Pharma AG, 65926 Frankfurt am Main, Germany.
Parasitol Res. 2003 Jun;90 Supp 1:S19-39. doi: 10.1007/s00436-002-0754-9. Epub 2003 Feb 26.
The group of biologically active nitroheterocyclic compounds includes various 5- and 2-nitroimidazoles and 5-nitrofurans, which can be used as therapeutic agents against a variety of protozoan and bacterial (anaerobic) infections of humans and animals. The current status in the the treatment of giardiasis, trichomoniasis, balantidiasis, histomoniasis, and amebiasis (including infections due to opportunistic amebas) is presented. The most relevant drugs (benznidazole, furazolidone, metronidazole, misonidazole, nifurtimox, nimorazole, nitazoxanide, ornidazole, secnidazole, and tinidazole) are characterized with regard to their chemical, chemotherapeutic, toxicological, pharmacokinetic, and pharmacological properties, including the mechanism of action and resistance in certain parasitic protozoa.
具有生物活性的硝基杂环化合物包括各种5-和2-硝基咪唑以及5-硝基呋喃，它们可用作治疗人类和动物各种原生动物和细菌（厌氧）感染的治疗剂。本文介绍了贾第虫病、滴虫病、小袋虫病、组织滴虫病和阿米巴病（包括机会性阿米巴引起的感染）治疗的现状。对最相关的药物（苯硝唑、呋喃唑酮、甲硝唑、米索硝唑、硝呋替莫、尼莫唑、硝唑尼特、奥硝唑、塞克硝唑和替硝唑）的化学、化疗、毒理学、药代动力学和药理学特性进行了描述，包括其作用机制和对某些寄生原生动物的耐药性。
